Genesis. 2004 Mar;38(3):130-8.

          Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice.

          Iwasato T, Nomura R, Ando R, Ikeda T, Tanaka M, Itohara S.

     Oncogene. 2004 Jun 24;23(29):5041-8.

              Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice.

              Oh J, Takahashi R, Adachi E, Kondo S, Kuratomi S, Noma A, Alexander DB, Motoda H, Okada A, Seiki M,
              Itoh T, Itohara S, Takahashi C, Noda M.

     Biochem Biophys Res Commun. 2004 Jan 23;313(4):850-5.

              Prion protein suppresses perturbation of cellular copper homeostasis under oxidative conditions.

              Sakudo A, Lee DC, Yoshimura E, Nagasaka S, Nitta K, Saeki K, Matsumoto Y, Lehmann S, Itohara S, Sakaguchi S, Onodera T.

     Circulation. 2004 Aug 3;110(5):571-8. Epub 2004 Jul 26.

              Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation
              of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.

              Augé N, Maupas-Schwalm F, Elbaz M, Thiers JC, Waysbort A, Itohara S, Krell HW, Salvayre R, Nègre-Salvayre A.

     Dev Biol. 2004 Jun 1;270(1):146-62.

              Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.

              Inoue T, Hatayama M, Tohmonda T, Itohara S, Aruga J, Mikoshiba K.

     Biochem Biophys Res Commun. 2004 Oct 8;323(1):218-22.

              Cellular prion protein regulates intracellular hydrogen peroxide level and prevents copper-induced apoptosis.

              Nishimura T, Sakudo A, Nakamura I, Lee DC, Taniuchi Y, Saeki K, Matsumoto Y, Ogawa M, Sakaguchi S, Itohara S, Onodera T.

     Brain Res Dev Brain Res. 2004 Oct 15;153(1):135-42.

              Expression of Btcl2, a novel member of Btcl gene family, during development of the central nervous system.

              Michishita M, Ikeda T, Nakashiba T, Ogawa M, Tashiro K, Honjo T, Doi K, Itohara S, Endo S.

     Hum Mol Genet. 2004 Oct 1;13(19):2183-96. Epub 2004 Aug 4.

              Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development
              of amyotrophic lateral sclerosis in a transgenic mouse model.

              Tateno M, Sadakata H, Tanaka M, Itohara S, Shin RM, Miura M, Masuda M, Aosaki T, Urushitani M, Misawa H, Takahashi R.

     Development. 2004 Apr;131(8):1825-33. Epub 2004 Mar 17.

              BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice.

              Yuhki M, Yamada M, Kawano M, Iwasato T, Itohara S, Yoshida H, Ogawa M, Mishina Y.

     J Biol Chem. 2004 Jan 30;279(5):3573-7. Epub 2003 Nov 26.

              Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental
              defects and results in embryonic lethality.

              Yoshida K, Furuya S, Osuka S, Mitoma J, Shinoda Y, Watanabe M, Azuma N, Tanaka H, Hashikawa T, Itohara S, Hirabayashi Y.


          Cell Tissue Res. 2004 Feb;315(2):147-56. Epub 2003 Nov 7.

          Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus.

          Sassa T, Gomi H, Itohara S.

     J Comp Neurol. 2004 Nov 15;479(3):243-56.

              Laminar organization of the developing lateral olfactory tract revealed by differential expression
              of cell recognition molecules.

              Inaki K, Nishimura S, Nakashiba T, Itohara S, Yoshihara Y.

     Cancer Cell. 2003 Jul;4(1):55-65.

              Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice.

              Ishida D, Kometani K, Yang H, Kakugawa K, Masuda K, Iwai K, Suzuki M, Itohara S, Nakahata T, Hiai H,    
              Kawamoto H, Hattori M, Minato N.

     Zoolog Sci. 2003 Dec;20(12):1439-45.

              Stimulus-induced behavior in F1 hybrids of seizure-sensitive and seizure-resistant gerbils.

              Seto-Ohshima A, Kitajima S, Ito M, Inoue M, Murashima YL, Yamakawa K, Itohara S.

     Biochem Biophys Res Commun. 2003 Oct 24;310(3):725-9.

              Tumor necrosis factor attenuates prion protein-deficient neuronal cell death by increases
              in anti-apoptotic Bcl-2 family proteins.

              Sakudo A, Lee DC, Saeki K, Matsumoto Y, Itohara S, Onodera T.

     Circulation. 2003 Sep 16;108(11):1375-81. Epub 2003 Aug 25.

              Deficiency of gelatinase a suppresses smooth muscle cell invasion and development of experimental intimal hyperplasia.

              Kuzuya M, Kanda S, Sasaki T, Tamaya-Mori N, Cheng XW, Itoh T, Itohara S, Iguchi A.

     J Cell Biol. 2003 Sep 15;162(6):1123-33.

              Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis.

              Wiseman BS, Sternlicht MD, Lund LR, Alexander CM, Mott J, Bissell MJ, Soloway P, Itohara S, Werb Z.

     J Gen Virol. 2003 Dec;84(Pt 12):3495-502.

              Transfection of prion protein gene suppresses coxsackievirus B3 replication in prion protein gene-deficient cells.

              Nakamura Y, Sakudo A, Saeki K, Kaneko T, Matsumoto Y, Toniolo A, Itohara S, Onodera T.

     Blood Cells Mol Dis. 2003 Mar-Apr;30(2):157-60.

              Runx3 is essential for the target-specific axon pathfinding of trkc-expressing dorsal root ganglion neurons.

              Inoue K, Ozaki S, Ito K, Iseda T, Kawaguchi S, Ogawa M, Bae SC, Yamashita N, Itohara S, Kudo N, Ito Y.

     EMBO J. 2003 Dec 15;22(24):6665-74. 

              The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model.

              Inoue H, Tsukita K, Iwasato T, Suzuki Y, Tomioka M, Tateno M, Nagao M, Kawata A, Saido TC, Miura M, Misawa H,
              Itohara S, Takahashi R.

     Biochem Biophys Res Commun. 2003 Aug 8;307(4):810-3.

              Expression of normal cellular prion protein (PrP(c)) on T lymphocytes and the effect of copper ion:
              Analysis by wild-type and prion protein gene-deficient mice.

              Kubosaki A, Nishimura-Nasu Y, Nishimura T, Yusa S, Sakudo A, Saeki K, Matsumoto Y, Itohara S, Onodera T.

     Biochem Biophys Res Commun. 2003 Aug 29;308(3):660-7.

              Impairment of superoxide dismutase activation by N-terminally truncated prion protein (PrP)
              in PrP-deficient neuronal cell line.

              Sakudo A, Lee DC, Saeki K, Nakamura Y, Inoue K, Matsumoto Y, Itohara S, Onodera T.

     Eur J Neurosci. 2003 Jul;18(1):134-42.

              Role of protein kinase C family in the cerebellum-dependent adaptive learning of horizontal optokinetic response
              eye movements in mice.

              Shutoh F, Katoh A, Ohki M, Itohara S, Tonegawa S, Nagao S.

     J Neurosci Res. 2003 May 1;72(3):279-89.

              Role of radial fibers in controlling the onset of myelination.

              Nakahara J, Takemura M, Gomi H, Tsunematsu K, Itohara S, Asou H, Ogawa M, Aiso S, Tan-Takeuchi K.

     Biochem Biophys Res Commun. 2003 Jul 4;306(3):680-6.

              A novel gene, Btcl1, encoding CUB and LDLa domains is expressed in restricted areas of mouse brain.

              Michishita M, Ikeda T, Nakashiba T, Ogawa M, Tashiro K, Honjo T, Doi K, Itohara S, Endo S.

     Electrophoresis. 2002 Dec;23(24):4167-74.

              Gerbils of a seizure-sensitive strain have a mitochondrial inner membrane protein with different isoelectric points
              from those of a seizure-resistant strain.

              Omori A, Ichinose S, Kitajima S, Shimotohno KW, Murashima YL, Shimotohno K, Seto-Ohshima A.

     Biochem Biophys Res Commun. 2002 Jun 7;294(2):280-6.

              Follicular dendritic cell of the knock-in mouse provides a new bioassay for human prions.

              Kitamoto T, Mohri S, Ironside JW, Miyoshi I, Tanaka T, Kitamoto N, Itohara S, Kasai N, Katsuki M, Higuchi J,
              Muramoto T, Shin RW.

     Hypertens Res. 2001 Nov;24(6):735-42.

              Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously
               hypertensive rats.

              Noguchi T, Ikeda K, Sasaki Y, Yamamoto J, Seki J, Yamagata K, Nara Y, Hara H, Kakuta H, Yamori Y.

     Nat Neurosci. 2002 Oct;5(10):946-54.

              Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons.

              Inoue K, Ozaki S, Shiga T, Ito K, Masuda T, Okado N, Iseda T, Kawaguchi S, Ogawa M, Bae SC, Yamashita N,
              Itohara S, Kudo N, Ito Y.

     Clin Exp Pharmacol Physiol. 2002 Nov;29(11):963-7.

              Effects of Ginkgo biloba extract (EGb 761) on cerebral thrombosis and blood pressure
              in stroke-prone spontaneously hypertensive rats.

              Sasaki Y, Noguchi T, Yamamoto E, Giddings JC, Ikeda K, Yamori Y, Yamamoto J.

     J Immunol. 2002 Sep 1;169(5):2643-7.

              The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis.

              Itoh T, Matsuda H, Tanioka M, Kuwabara K, Itohara S, Suzuki R.


          J Neurosci. 2002 Aug 15;22(16):6972-9.

          Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice.

          Takemura M, Gomi H, Colucci-Guyon E, Itohara S.

     J Neurosci. 2002 Nov 1;22(21):9171-5.

              Lesion-induced thalamocortical axonal plasticity in the S1 cortex is independent of NMDA receptor function
              in excitatory cortical neurons.

              Datwani A, Iwasato T, Itohara S, Erzurumlu RS.

     Mol Cell Neurosci. 2002 Nov;21(3):477-92.

              NMDA receptor-dependent pattern transfer from afferents to postsynaptic cells and dendritic differentiation
              in the barrel cortex.

              Datwani A, Iwasato T, Itohara S, Erzurumlu RS.

     Pharmacol Res. 2002 Aug;46(2):155-63.

              In vivo glioma growth requires host-derived matrix metalloproteinase 2 for maintenance of angioarchitecture.

              Takahashi M, Fukami S, Iwata N, Inoue K, Itohara S, Itoh H, Haraoka J, Saido T.

     Cell. 2002 Apr 5;109(1):113-24.

              Causal relationship between the loss of RUNX3 expression and gastric cancer.

              Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, Kim HM, Kim WJ,
              Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A,
              Sugimura T, Ushijima T, Bae SC, Ito Y.

     Hum Mol Genet. 2002 May 15;11(11):1251-62.

              Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia,
              myoclonus epilepsy and impaired behavioral response in mice.

              Ganesh S, Delgado-Escueta AV, Sakamoto T, Avila MR, Machado-Salas J, Hoshii Y, Akagi T, Gomi H, Suzuki T,
              Amano K, Agarwala KL, Hasegawa Y, Bai DS, Ishihara T, Hashikawa T, Itohara S, Cornford EM, Niki H, Yamakawa K.

     J Dermatol Sci. 2002 Feb;28(2):126-34.

              Expression of cellular prion-related protein by murine Langerhans cells and keratinocytes.

              Sugaya M, Nakamura K, Watanabe T, Asahina A, Yasaka N, Koyama Y, Kusubata M, Ushiki Y, Kimura K, Morooka A,
              Irie S, Yokoyama T, Inoue K, Itohara S, Tamaki K.

     Eur J Neurosci. 2002 Jan;15(1):40-50.

              Transgenic mice expressing a pH and Cl- sensing yellow-fluorescent protein under the control
              of a potassium channel promoter.

              Metzger F, Repunte-Canonigo V, Matsushita S, Akemann W, Diez-Garcia J, Ho CS, Iwasato T, Grandes P,
              Itohara S, Joho RH, Kn
öpfel T.


          Neurosci Lett. 2002 Mar 15;321(1-2):49-52.

          Normal development of serotonergic neurons in mice lacking S100B.

          Nishiyama H, Takemura M, Takeda T, Itohara S.

     J Neurosci Res. 2002 Jan 1;67(1):11-20.

              Disturbance of hippocampal long-term potentiation after transient ischemia in GFAP deficient mice.

              Tanaka H, Katoh A, Oguro K, Shimazaki K, Gomi H, Itohara S, Masuzawa T, Kawai N.

     Neurosci Res. 2002 Feb;42(2):141-5.

              Loss of adaptability of horizontal optokinetic response eye movements in mGluR1 knockout mice.

              Shutoh F, Katoh A, Kitazawa H, Aiba A, Itohara S, Nagao S.


          Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4037-42. Epub 2002 Mar 12.

          Glial protein S100B modulates long-term neuronal synaptic plasticity.

          Nishiyama H, Knopfel T, Endo S, Itohara S.


          Mech Dev. 2002 Feb;111(1-2):47-60.

          Complementary expression and neurite outgrowth activity of netrin-G subfamily members.

          Nakashiba T, Nishimura S, Ikeda T, Itohara S.


          Genes Cells. 2002 Mar;7(3):295-307.

          Distribution of phosphorylated glial fibrillary acidic protein in the mouse central nervous system.

          Takemura M, Nishiyama H, Itohara S.

     Clin Exp Pharmacol Physiol. 2004 Dec;31 Suppl 2:S24-6.

              Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis
              in stroke-prone spontaneously hypertensive rats.

              Noguchi T, Ikeda K, Sasaki Y, Yamamoto J, Yamori Y.

     Biol Reprod. 2001 Dec;65(6):1813-21.

              Placentomegaly in cloned mouse concepti caused by expansion of the spongiotrophoblast layer.

              Tanaka S, Oda M, Toyoshima Y, Wakayama T, Tanaka M, Yoshida N, Hattori N, Ohgane J, Yanagimachi R, Shiota K.

     FEBS Lett. 2001 Nov 16;508(2):187-90.

              Diminished corneal angiogenesis in gelatinase A-deficient mice.

              Kato T, Kure T, Chang JH, Gabison EE, Itoh T, Itohara S, Azar DT.

     Cell. 2001 Dec 14;107(6):789-800.

              The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis.

              Oh J, Takahashi R, Kondo S, Mizoguchi A, Adachi E, Sasahara RM, Nishimura S, Imamura Y, Kitayama H, Alexander DB,
              Ide C, Horan TP, Arakawa T, Yoshida H, Nishikawa S, Itoh Y, Seiki M, Itohara S, Takahashi C, Noda M.

     Nat Med. 2001 Nov;7(11):1202-8.

              Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor
              and allows safe antitumor therapy.

              Wielockx B, Lannoy K, Shapiro SD, Itoh T, Itohara S, Vandekerckhove J, Libert C.

     Biochem Biophys Res Commun. 2001 Mar 23;282(1):103-7.

              Distribution of cellular isoform of prion protein in T lymphocytes and bone marrow, analyzed by wild-type
              and prion protein gene-deficient mice.

              Kubosaki A, Yusa S, Nasu Y, Nishimura T, Nakamura Y, Saeki K, Matsumoto Y, Itohara S, Onodera T.

     Neuroreport. 2001 Sep 17;12(13):3003-7.

              Matrix metalloproteinase 2 gene knockout has no effect on acute brain injury after focal ischemia.

              Asahi M, Sumii T, Fini ME, Itohara S, Lo EH.


          J Biol Chem. 2001 Apr 6;276(14):11265-71. Epub 2001 Jan 10.

          In vivo conversion of cellular prion protein to pathogenic isoforms, as monitored by conformation-specific

          Yokoyama T, Kimura KM, Ushiki Y, Yamada S, Morooka A, Nakashiba T, Sassa T, Itohara S.

     Methods Mol Biol. 2001;158:135-54.

              Aggregation chimeras. Combining ES cells, diploid and tetraploid embryos.

              Tanaka M, Hadjantonakis AK, Nagy A.


          Nature. 2000 Aug 17;406(6797):726-31.

          Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex.

          Iwasato T, Datwani A, Wolf AM, Nishiyama H, Taguchi Y, Tonegawa S, Knöpfel T, Erzurumlu RS, Itohara S.

     J Neurosci Res. 2000 Apr 15;60(2):212-8.

              Involvement of glial fibrillary acidic protein (GFAP) expressed in astroglial cells in circadian rhythm under constant lighting
              conditions in mice.

              Moriya T, Yoshinobu Y, Kouzu Y, Katoh A, Gomi H, Ikeda M, Yoshioka T, Itohara S, Shibata S.

     Vet Pathol. 2000 Sep;37(5):415-21.

              Reduced formation of granulomata in gamma(delta) T cell knockout BALB/c mice inoculated
              with Mycobacterium avium subsp. paratuberculosis.

              Tanaka S, Itohara S, Sato M, Taniguchi T, Yokomizo Y.


          J Neurosci. 2000 Sep 1;20(17):6540-50. Links

          Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent
          from classical netrins.

          Nakashiba T, Ikeda T, Nishimura S, Tashiro K, Honjo T, Culotti JG, Itohara S.

     J Cell Biol. 2000 Sep 18;150(6):1499-506.

              Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis.

              Nagai N, Hosokawa M, Itohara S, Adachi E, Matsushita T, Hosokawa N, Nagata K.


          J Neurochem. 2000 May;74(5):1809-19. Links

          Identification of variants and dual promoters of murine serine/threonine kinase KKIAMRE.

          Sassa T, Gomi H, Sun W, Ikeda T, Thompson RF, Itohara S.

     J Neurochem. 2000 Sep;75(3):1085-91.

              Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.

              Iijima K, Ando K, Takeda S, Satoh Y, Seki T, Itohara S, Greengard P, Kirino Y, Nairn AC, Suzuki T.


          Learn Mem. 2000 Jul-Aug;7(4):220-6.

          Inhibition of nitric oxide synthesis and gene knockout of neuronal nitric oxide synthase
          impaired adaptation of mouse optokinetic response eye movements.

          Katoh A, Kitazawa H, Itohara S, Nagao S.

     Cell Immunol. 2000 May 25;202(1):61-9.

              gammadelta T cells may dichotomously modulate infection with avirulent Salmonella choleraesuis via IFN-gamma
              and IL-13 in mice.

              Naiki Y, Nishimura H, Itohara S, Yoshikai Y.

     Nature. 1999 Jul 15;400(6741):225-6.

              Prions prevent neuronal cell-line death.

              Kuwahara C, Takeuchi AM, Nishimura T, Haraguchi K, Kubosaki A, Matsumoto Y, Saeki K, Matsumoto Y, Yokoyama T,
              Itohara S, Onodera T.

     J Biochem. 1999 Oct;126(4):738-47.

              Studies on the cell-type specific expression of RBP-L, a RBP-J family member, by replacement insertion
              of beta-galactosidase.

              Minoguchi S, Ikeda T, Itohara S, Kaneko T, Okaichi H, Honjo T.

     J Immunol. 1999 Aug 15;163(4):2057-63.

              Regulatory role of peritoneal NK1.1+ alpha beta T cells in IL-12 production during Salmonella infection.

              Naiki Y, Nishimura H, Kawano T, Tanaka Y, Itohara S, Taniguchi M, Yoshikai Y.

     J Neurosci. 1999 Nov 1;19(21):9530-7.

              Learning induces a CDC2-related protein kinase, KKIAMRE.

              Gomi H, Sun W, Finch CE, Itohara S, Yoshimi K, Thompson RF.

     Microbiol Immunol. 1999;43(5):491-3.

              Insufficient resistance of trehalose-6,6-dimycolate-treated T-cell receptor delta gene mutant (TCR delta-/-) mice
              against influenza virus infection.

              Hoq MM, Suzutani T, Nakaya K, Yoshida I, Ogasawara M, Takeda Y, Shibaki T, Itohara S, Yamamoto H, Azuma M.

     Eur J Neurosci. 1999 Dec;11(12):4262-8.

              Doc2alpha is an activity-dependent modulator of excitatory synaptic transmission.

              Sakaguchi G, Manabe T, Kobayashi K, Orita S, Sasaki T, Naito A, Maeda M, Igarashi H, Katsuura G, Nishioka H, Mizoguchi A,
              Itohara S, Takahashi T, Takai Y.

     Neuron. 1999 Nov;24(3):701-13.

              Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3.

              Futatsugi A, Kato K, Ogura H, Li ST, Nagata E, Kuwajima G, Tanaka K, Itohara S, Mikoshiba K.

     Mech Dev. 1999 Sep;87(1-2):129-42.

              Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism
              highly resistant to genome-wide demethylation.

              Tanaka M, Puchyr M, Gertsenstein M, Harpal K, Jaenisch R, Rossant J, Nagy A.


          Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7705-10. 

          Dynamic characteristics and adaptability of mouse vestibulo-ocular and optokinetic response
          eye movements and the role of the flocculo-olivary system revealed by chemical lesions.

          Katoh A, Kitazawa H, Itohara S, Nagao S.



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